import re

from datetime import datetime, timezone, timedelta

def to_timestamp(dt_str, tz_str):

    dt = datetime.strptime(dt_str, '%Y-%m-%d %H:%M:%S')

    t_del = re.match(r'\w+?(\+?-?)(\d+?):00',tz_str)

    if t_del.group(1) == '+':

        m = int(t_del.group(2))

    elif t_del.group(1) == '-':

        m = -int(t_del.group(2))

    tz_utc_m = timezone(timedelta(hours=m))

    dt = dt.replace(tzinfo=tz_utc_m)

    return dt.timestamp()

t1 = to_timestamp('2015-6-1 08:10:30', 'UTC+7:00')

assert t1 == 1433121030.0, t1

t2 = to_timestamp('2015-5-31 16:10:30', 'UTC-09:00')

assert t2 == 1433121030.0, t2

print('ok')